BACKGROUND: The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study stopped recruiting patients because of higher-than-expected perioperative morbidity of primary stenting in patients with symptomatic intracranial stenosis. An alternative treatment, submaximal angioplasty without stenting, performed concurrently with SAMMPRIS, may offer revascularization benefits with a lower incidence of stenting-related risks. OBJECTIVE: To present the results of a consecutive case series of primary submaximal angioplasty procedures performed for symptomatic severe atherosclerotic intracranial stenosis refractory to medical treatment. Neurosurgery: December 2012 - Volume 71 - Issue 6 - p 1103–1110 doi: 10.1227/NEU.0b013e318271bcb8. Copyright © by the Congress of Neurological Surgeons
BACKGROUND AND PURPOSE: FDs are new intracranial stents designed to occlude aneurysms while preserving flow to jailed arterial branches. We tested this fundamental principle in a new aneurysm model. Published online before print May 3, 2012, doi: 10.3174/ajnr.A3075 AJNR 2012 33: 2004-2009 . Copyright © 2012 by American Journal of Neuroradiology
Purpose: To report midterm results of 3 cases in which drug-eluting balloons (DEBs) were successfully used for the management of carotid in-stent restenosis (ISR).
Purpose : To evaluate the safety and efficacy of drug-eluting balloons (DEB) for the treatment of in-stent restenosis (ISR) after carotid artery stenting (CAS).
Inflammation is a significant element of the pathogenesis of cerebral aneurysm formation and progression. Key processes include macrophages infiltration, smooth muscle cell differentiation and ultimately apoptosis, as well as upregulation of cytokines, adhesion molecules, and matrix remodeling genes.1 Following intravascular injury, monocyte chemoattractant protein-1 (MCP-1) induces monocytes to leave the bloodstream. This is an elemental aspect of atherosclerosis and MCP-1 over-expression has been found in abdominal aortic aneurysms, intracranial aneurysms and subarachnoid hemorrhage.2-4 In experimental models, MCP-1 was upregulated in aneurysm walls, and MCP-1 knockout mice demonstrated decreased expression of MMPs and inhibition of aneurysmal progression.5-6. Neurosurgery: December 2012 - Volume 71 - Issue 6 - p N10–N11 doi: 10.1227/01.neu.0000423039.66817.d7. Copyright © by the Congress of Neurological Surgeons
BACKGROUND AND PURPOSE: The PS is an innovative mechanical device designed to recanalize large-vessel occlusions by thrombus aspiration. The purpose of this study was to evaluate the effectiveness and neurologic outcome of patients treated with the PS in the setting of acute ischemic stroke. Published online before print March 29, 2012, doi: 10.3174/ajnr.A2990 AJNR 2012 33: 1488-1493. Copyright © 2012 by American Journal of Neuroradiology
Background—Periprocedural outcome has been extensively investigated in patients undergoing carotid artery stenting. However, risk factors contributing to long-term mortality have not been comprehensively assessed. We aimed to establish a validated clinical risk score for long-term mortality in patients after carotid artery stenting.
Background and Purpose—Hemianopia can cause considerable disability. Only scarce data are available for ischemic stroke patients presenting with isolated homonymous hemianopia and being treated with intravenous thrombolysis. We analyzed outcome of such patients registered in the Safe Implementation of Thrombolysis in Stroke–International Stroke Thrombolysis Register (SITS-ISTR). Stroke. 2012; 43: 2695-2698 Published online before print July 17, 2012, doi: 10.1161/STROKEAHA.112.658435. Copyright © 2012 American Heart Association, Inc. All rights reserved.
BACKGROUND AND PURPOSE: Recanalization is 1 drawback of the EVT of intracranial aneurysms. An analysis of the factors affecting the midterm anatomic results after EVT of ruptured intracranial aneurysms in a large multicenter series (CLARITY) is presented. Published online before print April 19, 2012, doi: 10.3174/ajnr.A3003 AJNR 2012 33: 1475-1480 . Copyright © 2012 by American Journal of Neuroradiology
Background and Purpose—The purpose of this study was to evaluate safety and efficacy of the Solitaire FR device in the treatment of patients with acute ischemic stroke secondary to large artery occlusion. Stroke. 2012; 43: 2699-2705 Published online before print July 31, 2012, doi: 10.1161/STROKEAHA.112.663328. Copyright © 2012 American Heart Association, Inc. All rights reserved.
Background and Purpose—Our goal was to investigate whether initial ischemic lesion pattern can predict stroke recurrence in patients with symptomatic intracranial arterial stenosis. 2012; 43: 2785-2787 Published online before print August 21, 2012, doi: 10.1161/STROKEAHA.112.659185. Copyright © 2012 American Heart Association, Inc. All rights reserved.
BACKGROUND AND PURPOSE: Flow-diverting devices are increasingly being considered for large or giant aneurysms with wide necks, which are difficult to treat with coils or clips. These devices are often oversized to achieve good positioning against the artery wall. The objective of this study was to analyze the effect of oversized flow-diverting devices in altering aneurysmal flows and creating hemodynamic environments favorable for thrombosis and aneurysm occlusion. Published online before print May 3, 2012, doi: 10.3174/ajnr.A3080 AJNR 2012 33: 2010-2016 . Copyright © 2012 by American Journal of Neuroradiology
Background and Purpose—The uncertain risk of secondary intracerebral hemorrhage (sICH) frequently keeps clinicians from initiating oral anticoagulation (OAC) early after ischemic cardioembolic stroke. The goal of this experimental study was to determine the risk of sICH depending on the timing of OAC initiation relative to stroke onset and to address the role of hematogenous macrophages for repair processes preventing OAC-associated sICH. Stroke. 2012; 43: 3352-3357 Published online before print November 1, 2012, doi: 10.1161/STROKEAHA.112.666818. Copyright © 2012 American Heart Association, Inc. All rights reserved.
Background and Purpose—To investigate the efficacy and safety of percutaneous transluminal angioplasty and stenting (PTAS) for symptomatic middle cerebral artery stenosis compared with standard medical treatment in a low-risk Chinese population. Stroke. 2012; 43: 3284-3290 Published online before print November 1, 2012, doi: 10.1161/STROKEAHA.112.662270. Copyright © 2012 American Heart Association, Inc. All rights reserved.
Background and Purpose—Impairments in cerebrovascular reserve (CVR) have been variably associated with increased risk of ischemic events and may stratify stroke risk in patients with high-grade internal carotid artery stenosis or occlusion. The purpose of this study is to perform a systematic review and meta-analysis to summarize the association of CVR impairment and stroke risk. Stroke. 2012; 43: 2884-2891 doi: 10.1161/STROKEAHA.112.663716. Copyright © 2012 American Heart Association, Inc. All rights reserved.
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