01 abril 2012

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Comparison of 5-Year Clinical Outcomes Between Sirolimus-Versus Paclitaxel-Eluting Stent. Korean Multicenter Network Analysis of 9000-Patient Cohort

Kyungil Park, MD, Kyung Woo Park, MD, Seung-Woon Rha, MD, Jang-Ho Bae, MD, Seung-Ho Hur, MD, Jong-Seon Park, MD, Jung-Han Yoon, MD, Yangsoo Jang, MD, Myung-Ho Jeong, MD and Hyo-Soo Kim, MD

Background—The paclitaxel-eluting stent (PES) and sirolimus-eluting stent (SES) are first-generation drug-eluting stents (DES) that have been the most widely used; however, it is unclear whether there are differences in the long-term safety and efficacy between the 2 stents. The long-term effectiveness of DES in unselected people with diabetes is also currently unclear. Moreover, the possibility of late catch-up is suggested in the DES population.

01 abril 2013

EUROPEAN HEART JOURNAL. Should duration of dual antiplatelet therapy depend on the type and/or potency of implanted stent? A pre-specified analysis from the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia study

Marco Valgimigli, Marco Borghesi, Matteo Tebaldi, Pascal Vranckx, Giovanni Parrinello, Roberto Ferrari, for the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY (PRODIGY) Investigators

Aims: The purpose of this pre-specified analysis of the PROlonging Dual antiplatelet treatment after Grading stent-induced Intimal hyperplasia studY (PRODIGY) was to assess device-specific outcomes relative to different duration of dual antiplatelet therapy (DAPT) after Everolimus- (EES), Paclitaxel (PES), Zotarolimus- (ZES-S) eluting, or bare metal stents (BMS).

01 abril 2012

AMERICAN JOURNAL OF ROENTGENOLOGY. Aortoiliac CT Angiography for Planning Transcutaneous Aortic Valve Implantation: Aortic Root Anatomy and Frequency of Clinically Significant Incidental Findings

Paul Apfaltrer, Gerhard Schymik, Peter Reimer, Holger Schroefel, Tim Sueselbeck, Thomas Henzler, Radko Krissak, John W. Nance, Jr, U. Joseph Schoepf, Dirk Wollschlaeger, Stefan O. Schoenberg and Christian Fink

OBJECTIVE. The purpose of this article is to assess aortic root and iliofemoral vessel anatomy and the frequency of clinically significant incidental findings on aortoiliac CT angiography (CTA) performed for planning of transcutaneous aortic valve implantation.

01 abril 2013

JACC. Comparison of Double Kissing Crush Versus Culotte Stenting for Unprotected Distal Left Main Bifurcation Lesions. Results From a Multicenter, Randomized, Prospective DKCRUSH-III Study

Shao-Liang Chen, MD; Bo Xu, MBBS; Ya-Ling Han, MD; Imad Sheiban, MD; Jun-Jie Zhang, MD; Fei Ye, MD; Tak W. Kwan, MD; Chitprapai Paiboon, MD; Yu-Jie Zhou, MD; Shu-Zheng Lv, MD; George D. Dangas, MD; Ya-Wei Xu, MD; Shang-Yu Wen, MD; Lang Hong, MD; Rui-Yan Zhang, MD; Hai-Chang Wang, MD; Tie-Ming Jiang, MD; Yan Wang, MD; Fang Chen, MD; Zu-Yi Yuan, MD; Wei-Min Li, MD; Martin B. Leon, MD

Objectives The study aimed to investigate the difference in major adverse cardiac event (MACE) at 1-year after double kissing (DK) crush versus Culotte stenting for unprotected left main coronary artery (UPLMCA) distal bifurcation lesions.

01 abril 2012

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Long-Term Follow-Up of Attenuated Plaques in Patients With Acute Myocardial Infarction. An Intravascular Ultrasound Substudy of the HORIZONS-AMI Trial

Kai Xu, MD, Gary S. Mintz, MD, Takashi Kubo, MD, PhD, Xiaofan Wu, MD, PhD, Ning Guo, MD, PhD, Junqing Yang, MD, Bernhard Witzenbichler, MD, Giulio Guagliumi, MD, Bruce Brodie, MD, Ovidiu Dressler, MD, Ecaterina Cristea, MD, Helen Parise, ScD, Roxana Mehran, MD, Gregg W. Stone, MD and Akiko Maehara, MD

Background—Intravascular ultrasound (IVUS)-attenuated plaque is characterized by absence of ultrasound signal behind hypoehcoic plaque and is seen almost exclusively in acute coronary syndromes.

01 marzo 2012

JACC CARDIOVASCULAR INTERVENTIONS. Incidence of Overall Bleeding in Patients Treated With Intra-Aortic Balloon Pump During Percutaneous Coronary Intervention. 12-Year Milan Experience

Giedrius Davidavicius, MD; Cosmo Godino, MD; Joanne Shannon, MD; Kensuke Takagi, MD; Letizia Bertoldi; Marco Mussardo, MD; Alaide Chieffo, MD; Francesco Arioli, MD; Alfonso Ielasi, MD; Mateo Montorfano, MD; Azeem Latib, MD; Antonio Colombo, MD

Objectives: This study aims to report a “real-world” experience of in hospital complications and clinical outcome of a large cohort of consecutive patients who underwent percutaneous coronary intervention (PCI) with intra-aortic balloon pump counterpulsation (IABP) support, from a tertiary care center over a 12-year period.

01 abril 2013

AMERICAN HEART JOURNAL. Clinical outcomes and cost implications of routine early PCI after fibrinolysis: One-year follow-up of the Trial of Routine Angioplasty and Stenting after Fibrinolysis to Enhance Reperfusion in Acute Myocardial Infarction

Akshay Bagai, MD , Warren J. Cantor, MD , Mary Tan, MSc , Wesley Tong, Hon, BSc , Andre Lamy, MD, MHSc , David Fitchett, MD , Eric A. Cohen, MD , Shamir R. Mehta, MD , Bjug Borgundvaag, MD , John Ducas, MD , Michael Heffernan, MD , Vladimír Džavík, MD , Laurie Morrison, MD , Brian Schwartz, MD , Charles Lazzam, MD , Anatoly Langer, MD , Shaun G. Goodman, MD, MSc

Background: In patients with ST-elevation myocardial infarction treated with fibrinolysis, routine early percutaneous coronary intervention (r-PCI) improves clinical outcomes at 30 days compared with a more standard approach of performing early PCI only for failed fibrinolysis (s-PCI).

01 abril 2012

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Impact of Frequency-Domain Optical Coherence Tomography Guidance for Optimal Coronary Stent Implantation in Comparison With Intravascular Ultrasound Guidance

Maoto Habara, MD, Kenya Nasu, MD, Mitsuyasu Terashima, MD, Hideaki Kaneda, MD, Daisuke Yokota, MD, Euihong Ko, MD, Tsuyoshi Ito, MD, Tairo Kurita, MD, Nobuyoshi Tanaka, MD, Masashi Kimura, MD, Tatsuya Ito, MD, Yoshihisa Kinoshita, MD, Etsuo Tsuchikane, MD, Keiko Asakura, MD, Yasushi Asakura, MD, Osamu Katoh, MD and Takahiko Suzuki, MD

Background—Frequency-domain optical coherence tomography (FD-OCT) is a novel, high resolution intravascular imaging modality. Intravascular ultrasound (IVUS) is a widely used conventional imaging modality for achieving optimal stent deployment. The aim of this study was to evaluate the impact of FD-OCT guidance for coronary stent implantation compared with IVUS guidance.

01 abril 2013

JACC. Diagnostic Classification of the Instantaneous Wave-Free Ratio Is Equivalent to Fractional Flow Reserve and Is Not Improved With Adenosine Administration. Results of CLARIFY

Sayan Sen, MBBS; Kaleab N. Asrress, MA, BM, BCh; Sukhjinder Nijjer, MB ChB; Ricardo Petraco, MD; Iqbal S. Malik, MBBS, PhD; Rodney A. Foale, MD; Ghada W. Mikhail, MBBS, MD; Nicolas Foin, PhD; Christopher Broyd, MBBS; Nearchos Hadjiloizou, MBBS, PhD; Amarjit Sethi, MBBS, PhD; Mahmud Al-Bustami, MD; David Hackett, MD; Masood A. Khan, MB, BChir, MA; Muhammed Z. Khawaja, MBBS; Christopher S. Baker, MBBS, PhD; Michael Bellamy, MBBS, MD; Kim H. Parker, PhD; Alun D. Hughes, MBBS, PhD; Darrel P. Francis, MB, BChir, MA; Jamil Mayet, MBChB, MD, MBA; Carlo Di Mario, MD, PhD; Javier Escaned, MD, PhD; Simon Redwood, MD; Justin E. Davies, MBBS, PhD

Objectives: This study sought to determine if adenosine administration is required for the pressure-only assessment of coronary stenoses.

01 abril 2013

JACC. Intracoronary Compared With Intravenous Bolus Abciximab Application During Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction

Ingo Eitel, MD; Jochen Wöhrle, MD; Henning Suenkel, BSc; Josephine Meissner, MD; Sebastian Kerber, MD; Bernward Lauer, MD; Matthias Pauschinger, MD; Ralf Birkemeyer, MD; Christoph Axthelm, MD; Rainer Zimmermann, MD; Petra Neuhaus, PhD; Oana Brosteanu, PhD; Suzanne de Waha, MD; Steffen Desch, MD; Matthias Gutberlet, MD; Gerhard Schuler, MD; Holger Thiele, MD

Objectives: The aim of the AIDA STEMI (Abciximab i.v. Versus i.c. in ST-elevation Myocardial Infarction) cardiac magnetic resonance (CMR) substudy was to investigate potential benefits of intracoronary versus intravenous abciximab bolus administration on infarct size and reperfusion injury in ST-segment elevation myocardial infarction.

01 marzo 2012

JACC CARDIOVASCULAR INTERVENTIONS. Transcatheter Mitral Valve-in-Valve Implantation in Patients With Degenerated Bioprostheses

Moritz Seiffert, MD; Lenard Conradi, MD; Stephan Baldus, MD; Johannes Schirmer, MD; Malgorzata Knap, MD; Stefan Blankenberg, MD; Hermann Reichenspurner, MD, PhD; Hendrik Treede, MD

Objectives: This study reports the results of a series of transapical mitral valve-in-valve implantations and aims to offer guidance on technical aspects of the procedure.

01 abril 2013

AMERICAN HEART JOURNAL. Radial versus femoral access, bleeding and ischemic events in patients with non–ST-segment elevation acute coronary syndrome managed with an invasive strategy

Marc W. Klutstein, MD , Cynthia M. Westerhout, PhD , Paul W. Armstrong, MD , Robert P. Giugliano, MD, SM , Basil S. Lewis, MD , C. Michael Gibson, MD , Sohrab Lutchmedial, MD , Petr Widimsky, MD, DrSc , P. Gabriel Steg, MD , Anthony Dalby, MD , Uwe Zeymer, MD , Frans Van de Werf, MD, PhD , Robert A. Harrington, MD , L. Kristin Newby, MD, MHS , Sunil V. Rao, MD

Background: Bleeding is a major limitation of antithrombotic therapy among invasively managed non–ST-segment elevation acute coronary syndromes (NSTE-ACS) patients; therefore, we examined the use of radial access and its association with outcomes among NSTE-ACS patients.

01 abril 2012

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. The Impact of Anemia on Long-Term Clinical Outcome in Patients Undergoing Revascularization With the Unrestricted Use of Drug-Eluting Stents

Thomas Pilgrim, MD, Florian Vetterli, MSc, Bindu Kalesan, MPH, Giulio G. Stefanini, MD, Lorenz Räber, MD, Stefan Stortecky, MD, Steffen Gloekler, MD, Ronald K. Binder, MD, Peter Wenaweser, MD, Aris Moschovitis, MD, Ahmed A. Khattab, MD, Lutz Buellesfeld, MD, Marcel Zwahlen, PhD, Bernhard Meier, MD, Peter Jüni, MD and Stephan Windecker, MD

Background—Anemia is frequent among patients with cardiovascular disease and adversely affects prognosis. The objective of this analysis was to assess the impact of anemia on long-term clinical outcomes among patients undergoing percutaneous coronary intervention (PCI) with the unrestricted use of drug-eluting stents (DES).

01 abril 2013

JACC. VERIFY (VERification of Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis Severity in EverydaY Practice)A Multicenter Study in Consecutive Patients

Objectives This study sought to compare fractional flow reserve (FFR) with the instantaneous wave-free ratio (iFR) in patients with coronary artery disease and also to determine whether the iFR is independent of hyperemia.

01 marzo 2013

JACC CARDIOVASCULAR INTERVENTIONS. Edge Vascular Response After Percutaneous Coronary Intervention. An Intracoronary Ultrasound and Optical Coherence Tomography Appraisal

Bill D. Gogas, MD; Hector M. Garcia-Garcia, MD, MSc, PhD; Yoshinobu Onuma, MD; Takashi Muramatsu, MD, PhD; Vasim Farooq, MBChB; Christos V. Bourantas, MD, PhD; Patrick W. Serruys, MD, PhD

The concept of edge vascular response (EVR) was first introduced with bare-metal stents and later with radioactive stents of various activity levels. Although radioactive stents reduced intra-stent neointimal hyperplasia and thereby the incidence of in-stent restenosis in a dose-dependent manner, tissue proliferation at the non-irradiated proximal and distal stent edges resulted in the failure of this invasive treatment. The advent of first- and second-generation drug-eluting stents (DES) reduced in-stent restenosis to approximately 5% to 10%, depending on the lesion subset and DES type. When in-segment restenosis (stent and 5-mm proximal and distal margins) occurred, it was most commonly focal and located at the proximal edge. In addition, stent thrombosis, the other main contributing factor for DES failure, seemed in part to be associated with residual plaque presence and underlying tissue composition at the landing zone of the implanted device, particularly if landed in a necrotic core rich milieu. More recently, the introduction of bioresorbable scaffolds for the treatment of coronary artery disease has prompted the re-evaluation of the EVR. This has recently been assessed up to 2-years after implantation of the Absorb bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, California). In general, the EVR consists of a focal but significant proximal lumen loss that in a few instances necessitates target lesion revascularization of a flow-limiting edge stenosis. Herein, we provide an overview of the in vivo evaluation of the EVR with intravascular ultrasound, virtual histology intravascular ultrasound, and the more recently developed optical coherence tomography. Our objective is to highlight the clinical importance of the EVR as a predisposing and contributing factor to device failure with either bare-metal stents, DES, or bioresorbable scaffolds.