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ESTUDIOS


19 septiembre 2017

CIRCULATION. Stellarex Drug-Coated Balloon for Treatment of Femoropopliteal Disease

Prakash Krishnan , Peter Faries , Khusrow Niazi , Ash Jain , Ravish Sachar , William B. Bachinsky , Joseph Cardenas , Martin Werner , Marianne Brodmann , J. A. Mustapha , Carlos Mena-Hurtado , Michael R. Jaff , Andrew H. Holden , Sean P. Lyden , Mark Mewissen , Barry Katzen , Aravinda Nanjundappa , Matheen A. Khuddus , Jason Ricci , Dennis Fry , Mehdi Shishehbor , Christopher Bosarge , Richard Kovach , Mark Goodwin , Mohammad Laiq Raja , Guy Mayeda , Jasvinder Sandhu , Oscar Rosales , William Crowder , David Paolini , John Henretta , Pratik Desai , Naim Farhat , Edward Kang , Gary Ansel , Mohammad Ghani , William Miller , Christopher Pollock , Ethan Korngold , John F. Angle , Greg Schultz , Todd Gensler , Louis Lopez , James Park , Georges Al-Khoury , Charles Joels and Christopher Metzger

Background: Drug-coated balloons (DCBs) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Because of the differences in excipients, paclitaxel dose, and coating morphologies, varying clinical outcomes have been observed with different DCBs. We report the results of 2 studies investigating the pharmacokinetic and clinical outcomes of a new DCB to treat femoropopliteal disease.

19 diciembre 2017

CIRCULATION. Radiation-Induced DNA Damage in Operators Performing Endovascular Aortic Repair

Tamer El-Sayed , Ashish S. Patel , Jun S. Cho , James A. Kelly , Francesca E. Ludwinski , Prakash Saha , Oliver T. Lyons , Alberto Smith , Bijan Modarai , M Tyrrell , P Gkoutzios , S Abisi , S Black , H Zayed , RE Bell , M Sallam , L Biasi , SD Patel , T Donati , M Dialynas , B Sandford , S Redwood , S Perera , A Pavlidis , B Prendergast and J Gill

Background: Radiation exposure during fluoroscopically guided interventions such as endovascular aortic repair (EVAR) is a growing concern for operators. This study aimed to measure DNA damage/repair markers in operators perfoming EVAR.

06 junio 2017

CIRCULATION. Low-Dose Paclitaxel–Coated Versus Uncoated Percutaneous Transluminal Balloon Angioplasty for Femoropopliteal Peripheral Artery Disease

Henrik Schroeder, Martin Werner, Dirk-Roelfs Meyer, Peter Reimer, Karsten Krüger, Michael R. Jaff and Marianne Brodmann

Background: Numerous studies have reported favorable outcomes using drug-coated balloons (DCBs) for treatment of symptomatic peripheral artery disease of the superficial femoral and popliteal arteries. However, the treatment effect compared with an uncoated balloon has differed greatly among the randomized trials, with better outcomes observed with higher-dose DCBs. This European trial was designed to assess the safety and effectiveness of a next-generation low-dose (2-µg/mm2 surface dose of paclitaxel) DCB.

29 agosto 2017

CIRCULATION. Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair

The MA3RS Study Investigators , David Newby , Rachael Forsythe , Olivia McBride , Jennifer Robson , Alex Vesey , Roderick Chalmers , Paul Burns , O James Garden , Scott Semple , Marc Dweck , Calum Gray , Tom MacGillivray , Chengjia Wang , Yolanda Georgia Koutraki , Neil Mitchard , Annette Cooper , Edwin van Beek , Graham McKillop , Weiyang Ho , Liz Fraser , Hayley Cuthbert , Peter Hoskins , Barry Doyle , Noel Conlisk , Wesley Stuart , Colin Berry , Giles Roditi , Laura Murdoch , Richard Holdsworth , Emma Scott , Lynsey Milne , Fiona Strachan , Fiona Wee , Katherine Oatey , Catriona Graham , Gordon Murray , Garry Milne , Marise Bucukoglu , Kirsteen Goodman , Jakub Kaczynski , Anoop Shah , Andrew Tambyraja , Julie Brittenden , Graeme Houston , Robert Lambie and John Norrie

Background: Ultrasmall superparamagnetic particles of iron oxide (USPIO) detect cellular inflammation on magnetic resonance imaging (MRI). In patients with abdominal aortic aneurysm, we assessed whether USPIO-enhanced MRI can predict aneurysm growth rates and clinical outcomes.

11 julio 2017

CIRCULATION. Thirty-Day Readmissions After Endovascular or Surgical Therapy for Critical Limb Ischemia

Dhaval Kolte, Kevin F. Kennedy, Mehdi H. Shishehbor, J. Dawn Abbott, Sahil Khera, Peter Soukas, Shafiq T. Mamdani, Omar N. Hyder, Douglas E. Drachman and Herbert D. Aronow

Background: Thirty-day readmission rates have gained increasing importance as a key quality metric. A significant number of patients are hospitalized for the management of critical limb ischemia (CLI), but limited data are available on the incidence, predictors, and causes of 30-day readmission after hospitalization for CLI.

01 noviembre 2016

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Outcomes of Endovascular Repair of Ascending Aortic Dissection in Patients Unsuitable for Direct Surgical Repair

Zhenjiang Li, Qingsheng Lu, Rui Feng, Jian Zhou, Zhiqing Zhao, Junmin Bao, Xiang Feng, Jiaxuan Feng, Yifei Pei, Chao Song and Zaiping Jing

Background: Stent grafting is a therapeutic option for patients who are unable to undergo urgent surgical repair of ascending aortic dissections. However, follow-up regarding outcomes is limited.

01 septiembre 2016

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Risk of Aortic Dissection in the Moderately Dilated Ascending Aorta

Joon Bum Kim, Matthew Spotnitz, Mark E. Lindsay, Thomas E. MacGillivray, Eric M. Isselbacher and Thoralf M. Sundt III

Background: Recent studies have demonstrated that many patients with acute type A aortic dissection (AD) have aortic diameters of <55 mm at presentation, prompting discussion of lowering the prophylactic surgical guidelines. However, risk of dissection at these smaller diameters is poorly defined.

01 junio 2016

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Ticagrelor for Prevention of Ischemic Events After Myocardial Infarction in Patients With Peripheral Artery Disease

Marc P. Bonaca, Deepak L. Bhatt, Robert F. Storey, Ph. Gabriel Steg, Marc Cohen, Julia Kuder, Erica Goodrich, José C. Nicolau, Alexander Parkhomenko, José López-Sendón, Mikael Dellborg, Anthony Dalby, Jindřich Špinar, Philip Aylward, Ramón Corbalán, Maria Teresa B. Abola, Eva C. Jensen, Peter Held, Eugene Braunwald and Marc S. Sabatine

Background: Peripheral artery disease (PAD) is associated with heightened ischemic and bleeding risk in patients with prior myocardial infarction (MI).

01 junio 2016

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Endovascular Repair Compared With Medical Management of Patients With Uncomplicated Type B Acute Aortic Dissection

Yong-Lin Qin, Feng Wang, Tian-Xiao Li, Wei Ding, Gang Deng, Bo Xie and Gao-Jun Teng

Background: Thoracic endovascular aortic repair (TEVAR) has been used in patients with uncomplicated type B acute aortic dissection (B-AAD) to reduce late morbidity and mortality. The outcomes of comparisons between TEVAR and best medical treatment (BMT) on patients with uncomplicated type B-AAD are inconsistent in the published reports.

01 junio 2016

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. First Experience With Percutaneous Mitral Valve Plication as Primary Therapy for Symptomatic Obstructive Hypertrophic Cardiomyopathy

Paul Sorajja, Wesley A. Pedersen, Richard Bae, John R. Lesser, Desmond Jay, David Lin, Kevin Harris and Barry J. Maron

Background: Few therapeutic options exist for patients with severe heart failure due to obstructive hypertrophic cardiomyopathy (HCM) who are at unacceptable surgical risk. We hypothesized that percutaneous plication of the mitral valve could reduce left ventricular outflow tract (LVOT) obstruction and associated mitral regurgitation, thereby leading to amelioration of heart failure symptoms.

01 septiembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Inferior Vena Cava Filters to Prevent Pulmonary Embolism: Systematic Review and Meta-Analysis

Behnood Bikdeli, Saurav Chatterjee, Nihar R. Desai, Ajay J. Kirtane, Mayur M. Desai, Michael B. Bracken, Frederick A. Spencer, Manuel Monreal, Samuel Z. Goldhaber and Harlan M. Krumholz

Background: Inferior vena cava (IVC) filters are widely used for prevention of pulmonary embolism (PE). However, uncertainty persists about their efficacy and safety.

01 octubre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. The Importance of Breakfast in Atherosclerosis Disease

Irina Uzhova, Valentín Fuster, Antonio Fernández-Ortiz, José M. Ordovás, Javier Sanz, Leticia Fernández-Friera, Beatriz López-Melgar, José M. Mendiguren, Borja Ibáñez, Héctor Bueno and José L. Peñalvo

Background: Daily habits, including the number and quality of eating occasions, are potential targets for primary prevention strategies with large health impacts. Skipping breakfast is considered a frequent and unhealthy habit associated with an increased cardiovascular (CV) risk.

01 noviembre 2017

JACC: CARDIOVASCULAR INTERVENTIONS. Heterogeneity of Ankle-Brachial Indices in Patients Undergoing Revascularization for Critical Limb Ischemia

Devraj Sukul, Scott F. Grey, Peter K. Henke, Hitinder S. Gurm and P. Michael Grossman

Objectives: This study sought to describe the distribution of pre-intervention treated-limb ankle-brachial indices (ABIs) among patients with critical limb ischemia (CLI) undergoing percutaneous vascular intervention (PVI) or surgical revascularization (SR).

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