01 noviembre 2012

STROKE. Antithrombotic Therapy and Bleeding Risk in a Prospective Cohort Study of Patients With Cerebral Cavernous Malformations

Hans-Martin Schneble, MD; Aicha Soumare, PhD; Dominique Hervé, MD, PhD; Damien Bresson, MD; Jean-Pierre Guichard, MD; Florence Riant, MD, PhD; Elisabeth Tournier-Lasserve, MD, PhD; Christophe Tzourio, MD, PhD; Hugues Chabriat, MD, PhD; Christian Stapf, MD

Background and Purpose—Cerebral cavernous malformations (CCMs) are one of the most frequently diagnosed vascular malformations of the brain and constitute a potential source of intracranial hemorrhage. In CCM patients suffering ischemic stroke or heart disease, the use of anticoagulants or antiplatelet therapy is generally avoided by fear of hemorrhagic complications, but no systematic studies exist to support this hypothesis. 2012; 43: 3196-3199 Published online before print November 13, 2012, doi: 10.1161/​STROKEAHA.112.668533. Copyright © 2012 American Heart Association, Inc. All rights reserved.

01 noviembre 2012

STROKE. Risk Prediction for Adverse Events After Carotid Artery Stenting in Higher Surgical Risk Patients

Neil J. Wimmer, MD; Robert W. Yeh, MD, MSc; Donald E. Cutlip, MD; Laura Mauri, MD, MSc

Background and Purpose—The goal of carotid artery stenting is to decrease the risk of stroke or other adverse events from carotid artery disease. Choosing a treatment strategy requires patient-specific information regarding periprocedural risk of adverse neurologic events. The aim of this study was to predict individual patient risk after carotid artery stenting in patients at higher risk for carotid endarterectomy. Stroke. 2012; 43: 3218-3224 Published online before print November 5, 2012, doi: 10.1161/​STROKEAHA.112.673194. Copyright © 2012 American Heart Association, Inc. All rights reserved.

01 noviembre 2012

STROKE. Stent-Based Thrombectomy Versus Intravenous Tissue Plasminogen Activator in Patients With Acute Middle Cerebral Artery Occlusion

Ronen R. Leker, MD FAHA; Roni Eichel, MD; John M. Gomori, MD; Fernando Ramirez de Noriega, MD; Tamir Ben-Hur, MD, PhD; Jose E. Cohen, MD

Background and Purpose—Our goal was to compare outcomes of patients with proximal middle cerebral artery occlusions treated with intravenous tissue plasminogen activator (tPA) with those of patients treated with stent-based thrombectomy (SBT). Stroke. 2012; 43: 3389-3391 Published online before print October 2, 2012, doi: 10.1161/​STROKEAHA.112.673665. Copyright © 2012 American Heart Association, Inc. All rights reserved.

01 noviembre 2012

JVIR. Stent Placement for Treatment of Long Segment (≥80mm) Carotid Artery Stenosis in Patients with Takayasu Disease

Jun Hu, MD, PhD , Heqing Huang, MD , Xiaofei Zhang, MD, MS , Guangjian Li, MD , Qu Liu, MD , Min Wu, MD , Gui Li, MD, PhD , Kangning Chen, MD, PhDemail address , Shugui Shi, MD, PhD

Purpose: To evaluate the effectiveness and safety of carotid artery stent (CAS) placement for treatment of long segment stenosis in patients with Takayasu arteritis. Journal of Vascular and Interventional Radiology Volume 23, Issue 11 , Pages 1473-1477, November 2012. November 2011. Copyright © 2012 SIR. Published by Elsevier Inc. All rights reserved.

15 noviembre 2012

STROKE. Final Infarct Volume Is a Stronger Predictor of Outcome Than Recanalization in Patients With Proximal Middle Cerebral Artery Occlusion Treated With Endovascular Therapy

Syed F. Zaidi, MD, Amin Aghaebrahim, MD, Xabier Urra, MD, Mouhammad A. Jumaa, MD, Brian Jankowitz, MD, Maxim Hammer, MD, Raul Nogueira, MD, Michael Horowitz, MD, Vivek Reddy, MD and Tudor G. Jovin, MD

Background and Purpose—The rationale for recanalization therapy in acute ischemic stroke is to preserve brain through penumbral salvage and thus improve clinical outcomes. We sought to determine the relationship between recanalization, clinical outcomes, and final infarct volumes in acute ischemic stroke patients presenting with middle cerebral artery occlusion who underwent endovascular therapy and post-procedure magnetic resonance imaging. STROKEAHA.112.671594 Published online before print November 15, 2012, doi: 10.1161/​STROKEAHA.112.671594. Copyright © 2012 American Heart Association, Inc.

01 noviembre 2012

STROKE. Persistent Hemodynamic Changes in Ruptured Brain Arteriovenous Malformations

Till Illies, MD; Nils Daniel Forkert, MSc; Dennis Saering, PhD; Karolin Wenzel; Thorsten Ries, MD; Jan Regelsberger, MD; Karl Wegscheider, PhD; Jens Fiehler, MD

Background and Purpose—Hemodynamic properties of brain arteriovenous malformations (AVMs) with risk factors for a future hemorrhage are essentially unknown. We hypothesized that AVMs with anatomic properties, which are associated with an increased rupture risk, exhibit different hemodynamic characteristics than those without these properties. Stroke. 2012; 43: 2910-2915 doi: 10.1161/​STROKEAHA.112.669945. Copyright © 2012 American Heart Association, Inc. All rights reserved.

13 septiembre 2012

STROKE. Associations Among Vascular Risk Factors, Carotid Atherosclerosis, and Cortical Volume and Thickness in Older Adults

Valerie A. Cardenas, PhD; Bruce Reed, PhD; Linda L. Chao, PhD; Helena Chui, MD; Nerses Sanossian, MD; Charles C. DeCarli, MD; Wendy Mack, PhD; Joel Kramer, PsyD; Howard N. Hodis, MD; Mingzhu Yan, MD, PhD; Michael H. Buonocore, MD, PhD; Owen Carmichael, PhD; William J. Jagust, MD; Michael W. Weiner, MD

Background and Purpose—The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness. Stroke. 2012; 43: 2865-2870 Published online before print September 13, 2012, doi: 10.1161/​STROKEAHA.112.659722. Copyright © 2012 American Heart Association, Inc. All rights reserved.

03 octubre 2012

NEUROSURGERY. Microcatheter Looping Technique for Coil Embolization of Complex Configuration Middle Cerebral Artery Aneurysms

Cho, Young Dae MD; Kang, Hyun-Seung MD. PhD; Kim, Jeong Eun MD. PhD; Son, Young Je MD. PhD; Lee, Jong Young MD; Lee, Seung Jin MD; Seo, Jung Hwa MD; Han, Moon Hee MD, PhD.

Background: Protection techniques using stents or microcatheters allow treatment of aneurysms with complex configurations by coil embolization. However, the application of these techniques is occasionally limited in wide neck middle cerebral artery (MCA) aneurysms with acute angularity of the efferent branch vessel. Neurosurgery: POST ACCEPTANCE, 3 October 2012 doi: 10.1227/NEU.0b013e318271ee1a. Copyright © by the Congress of Neurological Surgeons

04 septiembre 2012

STROKE. Transcranial Doppler Ultrasound for Screening Cerebral Small Vessel Disease

Vincent Mok, MD; Ding Ding, MD, MPH; Jianhui Fu, MD, PhD; Yunyun Xiong, MD, PhD; Winnie W.C. Chu, MD; Defeng Wang, PhD; Jill M. Abrigo, MD; Jie Yang, MD; Adrian Wong, PhD; Qianhua Zhao, MD; Qihao Guo, MD; Zhen Hong, MD; Ka Sing Wong, MD

Background and Purpose: We explored the association between pulsatility index (PI) as derived from transcranial Doppler ultrasound with various measures of small vessel disease in the community. Stroke. 2012; 43: 2791-2793 Published online before print September 4, 2012, doi: 10.1161/​STROKEAHA.112.665711. Copyright © 2012 American Heart Association, Inc.

13 septiembre 2012

STROKE. Detailed Analysis of Periprocedural Strokes in Patients Undergoing Intracranial Stenting in Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS)

David Fiorella, MD, PhD; Colin P. Derdeyn, MD; Michael J. Lynn, MS; Stanley L. Barnwell, MD, PhD; Brian L. Hoh, MD; Elad I. Levy, MD; Mark R. Harrigan, MD; Richard P. Klucznik, MD; Cameron G. McDougall, MD; G. Lee Pride Jr, MD; Osama O. Zaidat, MD, MS; Helmi L. Lutsep, MD; Michael F. Waters, MD, PhD; J. Maurice Hourihane, MD; Andrei V. Alexandrov, MD; David Chiu, MD; Joni M. Clark, MD; Mark D. Johnson, MD; Michel T. Torbey, MD, MPH; Zoran Rumboldt, MD; Harry J. Cloft, MD, PhD; Tanya N. Turan, MD; Bethany F. Lane, RN; L. Scott Janis, PhD; Marc I. Chimowitz, MB, ChB for the SAMMPRIS Trial Investigators

Background and Purpose—Enrollment in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial was halted due to the high risk of stroke or death within 30 days of enrollment in the percutaneous transluminal angioplasty and stenting arm relative to the medical arm. This analysis focuses on the patient and procedural factors that may have been associated with periprocedural cerebrovascular events in the trial. Stroke. 2012; 43: 2682-2688 Published online before print September 13, 2012, doi: 10.1161/​STROKEAHA.112.661173. Copyright © 2012 American Heart Association, Inc.

11 septiembre 2012

STROKE. National Trends in Utilization and Outcomes of Endovascular Treatment of Acute Ischemic Stroke Patients in the Mechanical Thrombectomy Era

Ameer E. Hassan, DO, Saqib A. Chaudhry, MD, Mikayel Grigoryan, MD, Wondwossen G. Tekle, MD and Adnan I. Qureshi, MD

Background and Purpose: Because several new devices for mechanical thrombectomy have become available, the outcomes of patients undergoing endovascular treatment for acute ischemic stroke are expected to improve in the United States. We performed this analysis to evaluate trends in utilization of endovascular treatment and associated rates of death and disability among acute ischemic stroke patients over a 6-year period, including further assessment within age strata. STROKEAHA.112.658781 Published online before print September 11, 2012, doi: 10.1161/​STROKEAHA.112.658781 Copyright © 2012 American Heart Association, Inc.

26 julio 2012

STROKE. Cerecyte Coil Trial. Angiographic Outcomes of a Prospective Randomized Trial Comparing Endovascular Coiling of Cerebral Aneurysms With Either Cerecyte or Bare Platinum Coils

Andrew J. Molyneux, FRCR; Alison Clarke, BA; Mary Sneade, BA; Ziyah Mehta, DPhil; Stuart Coley, FRCR; Daniel Roy, MD; David F. Kallmes, MD; Allan J. Fox, MD

Background and Purpose—We report the primary outcome of the Cerecyte Coil Trial, a randomized trial to determine whether polymer-loaded Cerecyte coils compared with Micrus bare platinum coils improved the proportion of patients with angiographic occlusion of the aneurysm at 6 months when assessed by a core laboratory. The secondary objectives were to compare the clinical outcomes and retreatment rates in the 2 groups. Stroke. 2012; 43: 2544-2550 Published online before print July 26, 2012, doi: 10.1161/​STROKEAHA.112.657254. Copyright © 2012 American Heart Association, Inc.

18 septiembre 2012

STROKE. Time Is Brain(stem) in Basilar Artery Occlusion

Mervyn D.I. Vergouwen, MD, PhD, Ale Algra, MD, PhD, Thomas Pfefferkorn, MD, Christian Weimar, MD, Christina M. Rueckert, MD, Vincent Thijs, MD, L. Jaap Kappelle, MD, PhD and Wouter J. Schonewille, MD on behalf of the Basilar Artery International Cooperation Study (BASICS) Study Group

Background and Purpose—The frequent use of a longer time window for recanalization therapy in patients with basilar artery occlusion (BAO) in daily practice is not supported by any scientific evidence. We investigated the relationship between time to recanalization therapy and functional outcome in BAO with data from the Basilar Artery International Cooperation Study (BASICS). STROKEAHA.112.666867 Published online before print September 18, 2012, doi: 10.1161/​STROKEAHA.112.666867. Copyright © 2012 American Heart Association, Inc.

10 mayo 2012

AJNR. Analysis of Intra-Aneurysmal Flow for Cerebral Aneurysms with Cerebral Angiography

L.-D. Jou and M.E. Mawad

BACKGROUND AND PURPOSE: Hemodynamics is an important factor in the development and rupture of cerebral aneurysms. Current techniques for measuring blood flow in cerebral aneurysms suffer from various limitations and have not been able to address our clinical needs. A new technique has been developed for effective evaluation of intra-aneurysmal flow based on high-frame-rate cerebral angiography, especially for flow-diverters. Published online before print May 10, 2012, doi: 10.3174/ajnr.A3057 AJNR 2012 33: 1679-1684. Copyright © 2012 by American Journal of Neuroradiology

12 abril 2012

AJNR. Preliminary Experience with the Percutaneous Embolization of Juvenile Angiofibromas Using Only Ethylene-Vinyl Alcohol Copolymer (Onyx) for Preoperative Devascularization Prior to Surgical Resection

J.J. Gemmete, S. Patel, A.S. Pandey, S.E. Sullivan, E.L. McKean, L.J. Marentette and N. Chaudhary

BACKGROUND AND PURPOSE: Juvenile angiofibromas are hypervascular tumors that may benefit from preoperative devascularization to reduce intraoperative blood loss. Our purpose was to evaluate the extent of angiographic devascularization and intraoperative blood loss by using only Onyx for percutaneous juvenile angiofibroma tumor embolization. Published online before print April 12, 2012, doi: 10.3174/ajnr.A3043 AJNR 2012 33: 1669-1675. Published online before print April 12, 2012, doi: 10.3174/ajnr.A3043 AJNR 2012 33: 1669-1675. Copyright © 2012 American Heart Association, Inc.